Vitamin K‐antagonistic effect of plastoquinone and ubiquinone derivatives in vitro
- 31 January 1994
- journal article
- Published by Wiley in FEBS Letters
- Vol. 338 (2) , 143-146
- https://doi.org/10.1016/0014-5793(94)80352-8
Abstract
Decyl‐ubiquinone and decyl‐plastoquinone were used as model compounds to test the potential effect of quinone derivatives on two enzymes of the vitamin K cycle in vitro. Substantial inhibition of γ‐glutamate carboxylase was found, whereas vitamin K‐epoxide reductase was inhibited to a much lesser extent. The inhibitory effect of both decylquinones was eliminated in a time‐dependent way by solubilized microsomes, but not by purified carboxylase. Since a wide variety of prenylquinones occur as micronutrients, these results are of potential relevance for the effects of natural quinones in the human diet.Keywords
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