DEPRESSION OF THE EXOGENOUS CREATININE/INULIN OR THIOSULFATE CLEARANCE RATIOS IN MAN BY DIODRAST AND p-AMINOHIPPURIC ACID 1

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Abstract
In normal man, the exogenous creatinine clearance exceeds the simultaneous inulin or thiosulfate clearance to an extent clearly beyond the limits of experimental error. In 39 periods in 7 subjects, the thiosulfate/inulin clearance ratio averages 0.98, confirming the conclusion of Newman, Gilman and Phillips that the thiosulfate clearance is at the level of glomerular filtration. The admn. of large doses of diodrast or PAH (substances known to be copiously excreted by the renal tubules in man) depresses the creatinine/inulin and crea-tinine/thiosulfate ratio to or towards 1.0. These facts are presented as new evidence for the tubular excretion of exogenous creatinine, and confirm the belief that in man as in other mammals the inulin clearance is at the level of glomerular filtration.