INDUCTION OF TUMORS IN MICE WITH HERBICIDE SUCCINIC ACID 2,2-DIMETHYLHYDRAZIDE

  • 1 January 1977
    • journal article
    • research article
    • Vol. 37  (10) , 3497-3500
Abstract
A solution of 2% succinic acid 2,2-dimethylhydrazide was given continuously in the drinking water of 6 wk old randomly bred albino mice for the remainder of their lives. The treatment gave rise to tumors of blood vessels, lungs and kidneys. The tumor incidences in these tissues in the controls were 6, 18 and 0%, whereas in the treated groups the corresponding tumor incidences was 73, 73 and 5%. Light microscopic examination revealed typical angiomas and angiosarcomas of blood vessels, adenomas and adenocarcinomas of lungs and adenomas of kidneys. The study demonstrates the tumorigenicity of the herbicide, succinic acid 2,2-dimethylhydrazide. Since the residues of this chemical occur in fruit, the human population is exposed to it. The environmental implication of this finding and the fact that the hydrazines as a class have tumorigenic properties are discussed.