Thermal Degradation of Famotidine in Aqueous Solution Stability Indicating Assay
- 1 October 1992
- journal article
- pharmaceutical analysis
- Published by Taylor & Francis in Analytical Letters
- Vol. 25 (10) , 1907-1913
- https://doi.org/10.1080/00032719208018261
Abstract
A High Pressure Liquid Chromatographic Method is described for the determination of famotidine in aqueous solution. The assay method is capable of distinguishing famotidine from its thermal degradation products in the pH range of 1.7–10.0. Famotidine and the internal standard sulfacetamide eluted in 13 minutes with retention times of 10 and 5.7, respectively. A linear relationship between peak height ratio (famotidine/sulfacetamide) and famotidine concentration was found up to 60 μg/ml. The coefficient of variation of the assay method over several days ranged from 0.2 to 5.1% in the concentration range of 4–57 μg/ml.Keywords
This publication has 4 references indexed in Scilit:
- Validation of a method for the assay of related compounds in famotidine raw materials and formulationsJournal of Pharmaceutical and Biomedical Analysis, 1989
- Quantitation of Famotidine in Pharmaceutical Dosage Forms Using High-Performance Liquid ChromatographyDrug Development and Industrial Pharmacy, 1989
- Reversed-phase determination of famotidine, potential degradates, and preservatives in pharmaceutical formulations by high-performance liquid chromatography using silica as a stationary phaseJournal of Chromatography A, 1986
- Analytical method for the quantification of famotidine, an H2-receptor blocker, in plasma and urineJournal of Chromatography B: Biomedical Sciences and Applications, 1985