Kinetics of R and S warfarin enantiomers
- 1 July 1980
- journal article
- research article
- Published by Wiley in Clinical Pharmacology & Therapeutics
- Vol. 28 (1) , 99-105
- https://doi.org/10.1038/clpt.1980.137
Abstract
A method is reported for simultaneous measurement of the kinetics of R and S warfarin enantiomers [anticoagulant]. Pure pentadeuterated R and S enantiomers were each combined with unlabeled enantiomers to form pseudo -racemic mixtures which were given (0.75 mg/kg) to 5 healthy subjects. Plasma R and S enantiomer levels were measured by gas chromatography-mass spectrometry. Elimination half-lifes (t 1/2) and volumes of distribution (Vd) of the enantiomers were not altered by the presence of the other.This publication has 8 references indexed in Scilit:
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