IMMUNE AND BIOCHEMICAL MECHANISMS IN ALLERGIC DISEASE OF UPPER RESPIRATORY-TRACT - ROLE OF ANTIBODIES, TARGET-CELLS, MEDIATORS AND EOSINOPHILS

  • 1 January 1977
    • journal article
    • review article
    • Vol. 38  (2) , 83-90
Abstract
The pathways leading to the development of the allergic state and subsequently to the characteristic inflammatory response are complex and result from an interplay between immunologic and biochemical events. Several intrinsic factors, i.e., handling of antigens at mucosal level, transient immunodeficiency states (especially in the secretory IgA [immunoglobulin A] system), impairment in the IgE regulatory mechanism, modulation of cyclic nucleotides leading to mediator release and a feedback inhibition control provided by histamine and eosinophil derived products greatly dictate the outcome of events associated with allergic inflamation.