The relation of ventilation to metabolic rate during moderate exercise in man

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Abstract
To characterize more precisely the relationship between ventilation (V E) and CO2 output (VCO2) during incremental exercise, 35 healthy males were studied at rest and during upright cycle ergometry, with the work rate incremented every 4 min up to each subject's anaerobic threshold (θ an). Twenty-one subjects had arterial blood sampled at rest and in the steady state at each work rate to determine the relationship between physiological dead space ventilation (V D) and VCO2. At these work rates arterial PCO2 was regulated at the resting, control value. V E (BTPS) was linearly related to VCO2 from rest to θ an with a slope of 24.6. However, the regression had a significant positive intercept of 3.2 L·min−1. This causes the ventilatory equivalent for CO2 (i.e., V E/VCO2) to decrease with increasing work rates. V D also increased linearly with increasing VCO2. However, this was consequent to increased breathing frequency as V D remained constant. Thus, the observed fall in V E/VCO2 with increasing work rates is due to the positive intercept but the inherent relationship between V E and VCO2, reflected by the linear regression slope, remains unchanged from rest through moderate exercise.