FDG-PET for the evaluation of tumor viability after anticancer therapy
- 1 June 1994
- journal article
- research article
- Published by Springer Nature in Annals of Nuclear Medicine
- Vol. 8 (2) , 109-113
- https://doi.org/10.1007/bf03165015
Abstract
To evaluate positron emission tomography with18F-fluorodeoxy glucose (FDG-PET) as an diagnostic tool to determine tumor viability after anticancer therapy, fourteen patients were examined by FDG-PET after the end of the treatment. The lesions with residual viable tumor cells showed higher uptake of FDG than surrounding normal soft tissue. The lesions, in which tumor viability was lost or very low, showed higher uptake of FDG in four cases and similar uptake to normal soft tissue in three cases. The residual increased uptake of FDG was considered to be caused by remaining tumor cells and/or inflammatory reaction to anticancer treatment. FDG-PET after anticancer treatment should be interpreted by considering the reaction due to the treatment and the partial volume artifact of PET caused by the limited spatial resolution.Keywords
This publication has 11 references indexed in Scilit:
- Intratumoral distribution of fluorine-18-fluorodeoxyglucose in vivo: high accumulation in macrophages and granulation tissues studied by microautoradiography.1992
- Positron emission tomography using fluorine-18-fluorodeoxyglucose in malignant lymphoma: a comparison with proliferative activity.1992
- PET studies of fluorodeoxyglucose metabolism in patients with recurrent colorectal tumors receiving radiotherapy.1991
- Primary and metastatic breast carcinoma: initial clinical evaluation with PET with the radiolabeled glucose analogue 2-[F-18]-fluoro-2-deoxy-D-glucose.Radiology, 1991
- The use of FDG-PET in the detection and management of malignant lymphoma: correlation of uptake with prognosis.1991
- Positron Emission Tomography Using [18F] Fluorodeoxyglucose in Brain Tumors A Powerful Diagnostic and Prognostic ToolInvestigative Radiology, 1987
- Comparative Regional Analysis of 2-Fluorodeoxyglucose and Methylglucose Uptake in Brain of Four Stroke Patients. With Special Reference to the Regional Estimation of the Lumped ConstantJournal of Cerebral Blood Flow & Metabolism, 1985
- Estimation of Local Cerebral Glucose Utilization by Positron Emission Tomography of [18F]2-Fluoro-2-Deoxy-D-Glucose: A Critical Appraisal of Optimization ProceduresJournal of Cerebral Blood Flow & Metabolism, 1985
- Graphical Evaluation of Blood-to-Brain Transfer Constants from Multiple-Time Uptake DataJournal of Cerebral Blood Flow & Metabolism, 1983
- Quantitation in Positron Emission Computed TomographyJournal of Computer Assisted Tomography, 1979