Lymphatic Innervation
- 1 January 1990
- journal article
- review article
- Published by S. Karger AG in Journal of Vascular Research
- Vol. 27 (2-5) , 127-136
- https://doi.org/10.1159/000158803
Abstract
Bovine mesenteric lymphatic vessels have nerves in their walls which in response to field stimulation cause an increase in freqency of spontaneous lymphatic contractions and this could be blocked by α-antagonists. When vessels were loaded with [3H]-noradrenaline, 3H-effiux was increased in response to field stimulation and this was potentiated by α2-antagonists and depressed by α2-agonists. Electrical activity in these vessels consisted of a single action potential which preceded each contraction. Mean resting potential was –61 mV ± 5.7 (SD). Stimulation of postsynaptic α-receptors caused a depolarization accompanied by a decrease in membrane conductance while β-receptor stimulation had the opposite effect. Lymphatic noradrenergic nerves appear to have a role in the living animal since stimulation of the sympathetic chain in anaesthetized sheep increased popliteal efferent lymph flow and this could be blocked by α-adrenergic blockers.Keywords
This publication has 0 references indexed in Scilit: