SYNTHESIS AND BIOLOGICAL EFFECT OF THE C-TERMINAL PENTAPEPTIDE AMIDE OF AVIAN PANCREATIC HORMONE III (APP)
- 12 January 2009
- journal article
- research article
- Published by Wiley in International Journal of Peptide and Protein Research
- Vol. 13 (2) , 201-206
- https://doi.org/10.1111/j.1399-3011.1979.tb01869.x
Abstract
Model building studies and analogies drawn from peptides of similar biological activity have indicated that the C-terminus of avian pancreatic hormone III may possess significant biological information. To test this hypothesis, the C-terminal pentapeptide amide sequence was synthesized by the Merrifield method. The synthesis, purification and characterization of this compound were reported in detail. In vivo studies [using chickens] indicated that this synthetic segment possesses none of the secretogogic activity of the parent hormone. Rather, it reduces gastric secretion levels even in the presence of the intact hormone.Keywords
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