Effect of Pentobarbital Anesthesia on Tmpah in the Dog

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Abstract
Tmpah was determined with and without pentobarbital anesthesia in six mongrel female dogs with both kidneys explanted to a subcutaneous position. A consistent 26.5% depression of Tmpah was seen in the anesthetized animals, as judged by the combined means of 12 experiments with anesthesia and 12 experiments without anesthesia. The depression was manifested as early as 1 1/2 hours after induction of anesthesia, and was constant for at least 1 hour. Anesthesia caused no change in glomerular filtration rate, effective renal plasma flow, or filtration fraction.

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