Type-specific monoclonal antibodies produced to proteins of Murray Valley encephalitis virus
- 1 February 1988
- journal article
- research article
- Published by Wiley in Immunology & Cell Biology
- Vol. 66 (1) , 51-56
- https://doi.org/10.1038/icb.1988.6
Abstract
Two monoclonal antibodies have been produced to the flavivirus, Murray Valley encephalitis (MVE). Immunofluorescent antibody and ELISA tests revealed that one antibody was specific for MVE while the other cross-reacted weakly with Alfuy and Kunjin viruses. These antibodies have neither haemagglutination inhibition nor neutralising activity. One of the monoclonal antibodies reacted with the envelope glycoprotein (E) and a 45,000 MW protein, while the other reacted with a protein of 23,000 daltons. Competitive binding assays confirmed that these antibodies reacted with unrelated epitopes.Keywords
This publication has 23 references indexed in Scilit:
- An Enzyme Immunoassay to Detect Australian Flaviviruses and Identify the Encephalitic Subgroup using Monoclonal AntibodiesImmunology & Cell Biology, 1987
- Illness caused by a Kokobera‐like virus in south‐eastern AustraliaThe Medical Journal of Australia, 1986
- Topographical analysis of epitope relationships on the envelope glycoprotein of yellow fever 17D vaccine and the wild type asibi parent virusVirology, 1986
- Examination of the Immunological Relationships between Flaviviruses Using Yellow Fever Virus Monoclonal AntibodiesJournal of General Virology, 1985
- Epitopic Analysis of Antigenic Determinants on the Surface of Dengue-2 Virions Using Monoclonal Antibodies *The American Journal of Tropical Medicine and Hygiene, 1985
- Yellow Fever Monoclonal Antibodies: Type-Specific and Cross-Reactive Determinants Identified by ImmunofluorescenceThe American Journal of Tropical Medicine and Hygiene, 1984
- Mosquito Cell Cultures and Specific Monoclonal Antibodies in Surveillance for Dengue VirusesThe American Journal of Tropical Medicine and Hygiene, 1984
- Dengue Virus-Specific and Flavivirus Group Determinants Identified with Monoclonal Antibodies by Indirect ImmunofluorescenceThe American Journal of Tropical Medicine and Hygiene, 1982
- Monoclonal Antibodies Against the Flavivirus West NileJournal of General Virology, 1982
- ARTHROPOD‐BORNE VIRUSES IN AUSTRALIA, 1973‐1976Immunology & Cell Biology, 1977