Hydroxyurea: Suppression of Two-Stage Carcinogenesis in Mouse Skin
- 3 April 1970
- journal article
- Published by American Association for the Advancement of Science (AAAS) in Science
- Vol. 168 (3927) , 130-132
- https://doi.org/10.1126/science.168.3927.130
Abstract
Hydroxyurea, a selective cytotoxic agent for cells in DNA synthesis, injected intraperitoneally at 24 and 48 hours after the first painting with 1 percent croton oil, significantly reduced the tumor yield in the two-stage chemical carcinlogenesis in mouse skin. A comparable group of mice receiving hydroxyurea only once at 24 hours had a tumor induction similar to that in controls.Keywords
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