Functional Analysis of the Promoter of theSaccharomyces cerevisiaeMultidrug Resistance GeneYDR1, which Encodes a Member of the ATP Binding Cassette (ABC) Superfamily
- 1 January 1995
- journal article
- Published by Taylor & Francis in Bioscience, Biotechnology, and Biochemistry
- Vol. 59 (1) , 147-149
- https://doi.org/10.1271/bbb.59.147
Abstract
The Saccharomyces cerevisiae gene YDR1/PDR5/STS1, which encodes a member of the ATP binding cassette (ABC) superfamily, is important for cross-resistance to apparently unrelated drugs. The expression of YDR1 is induced by various drugs and heat shock [Hirata et al., Curr. Genet., 26, 285-294 (1994)]. By deletion analysis of the 5'-noncoding region of the YDR1 gene, two drug responsive regions (-604 to -485 and -335 to -275) were identified with fluphenazine and cycloheximide. Three conserved palindrome sequences were found in these regions.Keywords
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