Probabilities of orders in linkage calculations
- 1 October 1990
- journal article
- Published by Wiley in Annals of Human Genetics
- Vol. 54 (4) , 339-363
- https://doi.org/10.1111/j.1469-1809.1990.tb00389.x
Abstract
SUMMARY: The present state of linkage estimation procedures is surveyed. When information on linkage between several loci on one chromosome is given in the form of lod scores or likelihoods, a method is developed for finding the probabilities of the different possible orders of the loci, and the distribution of the map distances between them. This depends largely on a Monte Carlo method of integrating the probabilities.Keywords
This publication has 16 references indexed in Scilit:
- Counting algorithms for linkageAnnals of Human Genetics, 1990
- The CEPH consortium primary linkage map of human chromosome 10Genomics, 1990
- Some simple methods for linkage analysisAnnals of Human Genetics, 1989
- Demonstration of a sex difference in recombination fraction in the loose linkage, Rh and PGM1Annals of Human Genetics, 1972
- THE MAPPING OF HUMAN CHROMOSOMESAnnual Review of Genetics, 1971
- Further linkage scores and corrections in two‐ and three‐generation familiesAnnals of Human Genetics, 1969
- Stocks for detecting linkage in the mouse, and the theory of their designJournal of Genetics, 1951
- The Theory of Genetical RecombinationAdvances in Genetics, 1950
- THE ESTIMATION OF MAP DISTANCES FROM RECOMBINATION VALUESAnnals of Eugenics, 1943
- Outline of a Theory of Statistical Estimation Based on the Classical Theory of ProbabilityPhilosophical Transactions of the Royal Society of London. Series A, Mathematical and Physical Sciences, 1937