Effect of Synthetic Thyrotropin-Releasing Hormone on Glucose Oxidation and Phospholipogenesis in Porcine Anterior Pituitary Slices in the Presence or Absence of Thyroid Hormone
- 1 February 1973
- journal article
- research article
- Published by Frontiers Media SA in Experimental Biology and Medicine
- Vol. 142 (2) , 516-520
- https://doi.org/10.3181/00379727-142-37058
Abstract
Summary Synthetic TRH stimulated the oxidation of 14C-1 -glucose and 14C-6-glucose to 14CO2 in porcine anterior pituitary slices. This effect of TRH on the oxidation of 14C-6-glucose was greater than that of 14C-1-glucose. Thyroxine blocked the increase of glucose oxidation produced by TRH, but failed to do so in the presence of actinomycin D. Synthetic TRH also stimulated 32P incorporation into phospholipids, the magnitude of stimulation being related to the dose of TRH used. DBcAMP also stimulated phos-pholipogenesis by the anterior pituitary. TRH stimulation of pituitary phospholipogenesis was not inhibited by triiodothyronine.Keywords
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