MECHANISMS OF THE RELAXANT ACTION OF KETAMINE ON ISOLATED PORCINE TRACHEALIS MUSCLE
Open Access
- 1 October 1993
- journal article
- research article
- Published by Elsevier in British Journal of Anaesthesia
- Vol. 71 (4) , 544-550
- https://doi.org/10.1093/bja/71.4.544
Abstract
Ketamine is a potent bronchodilator, but its mode of action is unclear. We have studied the effect of ketamine on the peripheral vagus nerve motor pathway of isolated porcine trachealls muscle. Posts ynaptic nicotinic cholinergic receptors of the intramural ganglia were stimulated selectively with 1,1-dimethyl-4-phenyl-piperazinium iodide, postganglionic nerve fibres with electrical field stimulation (in the presence of hexamethonium) and muscarinic cholinergic receptors with acetylcholine (in the presence of tetrodotoxin). Ketamine 10−4 mol litre−1 significantly shifted the concentration-response curves of acetylcholine (P < 0.02) and electrical field stimulation (P P 2adrenoceptors are not involved in the mechanism of relaxation. (Br. J. Anaesth. 1993; 71: 544–550)Keywords
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