Pathophysiological correlates of thallium-201 myocardial uptake in experimental infarction

1 March 1977

journal article
research article
Published by Oxford University Press (OUP) in Cardiovascular Research

Vol. 11 (2) , 141-146
https://doi.org/10.1093/cvr/11.2.141

Abstract

The pathophysiological correlates of thallium-201 (201T1) myocardial uptake were studied in a 24-hour-old closed-chest canine infarct model. Reduction in regional 201T1 uptake correlated well with the magnitude of tissue creatine phosphokinase depletion and microsphere estimates of transmural blood flow. In low flow endocardial regions 201T1 occasionally underestimated the magnitude of flow reduction. Even slight reductions of 201T1 uptake (<0.86 of normal) were associated with histopathological and histochemical evidence of necrosis.