Chromogranin A‐Activated Microglial Cells Induce Neuronal Apoptosis
- 1 October 2002
- journal article
- review article
- Published by Wiley in Annals of the New York Academy of Sciences
- Vol. 971 (1) , 560-562
- https://doi.org/10.1111/j.1749-6632.2002.tb04527.x
Abstract
Abstract: Chromogranin (CgA), a protein upregulated in many neuropathologies, can induce an activated phenotype in microglial cells that leads to neuronal apoptosis. The death‐signaling pathways mobilized in neurons involve the death receptor Fas, p38 MAP kinase, and mitochondrial cytochrome c. We propose that CgA represents a potent endogenous inflammatory factor responsible for neuronal degeneration.Keywords
This publication has 5 references indexed in Scilit:
- Mechanisms Underlying Neuronal Death Induced by Chromogranin A-activated MicrogliaPublished by Elsevier ,2001
- Apoptotic Pathways Mobilized in Microglia and Neurones as a Consequence of Chromogranin A‐Induced Microglial ActivationJournal of Neurochemistry, 1999
- Identification of Microglial Signal Transduction Pathways Mediating a Neurotoxic Response to Amyloidogenic Fragments of β-Amyloid and Prion ProteinsJournal of Neuroscience, 1999
- Chromogranin A Induces a Neurotoxic Phenotype in Brain Microglial CellsJournal of Biological Chemistry, 1998
- Chromogranin a triggers a phenotypic transformation and the generation of nitric oxide in brain microglial cellsNeuroscience, 1996