2',3'-Bis(2-chloroethyl)aminophosphoryl-3'-amino-3'-deoxyadenosine: a cyclic nucleotide with antitumor activity
- 1 July 1979
- journal article
- research article
- Published by American Chemical Society (ACS) in Journal of Medicinal Chemistry
- Vol. 22 (7) , 882-885
- https://doi.org/10.1021/jm00193a026
Abstract
The synthesis of the title compound from 3''-amino-3''-deoxyadenosine in 40% yield is reported. 3''-Amino-3''-deoxyadenosine was made by an improved synthesis in 12 steps from inexpensive D-xylose in 15% overall yield. Both isomers of the title compound separated by column chromatography possess confirmed activity against KB [human oral epidermoid carcinoma] tumor cell cultures.This publication has 1 reference indexed in Scilit:
- Zur Reaktion von Aminonucleosiden mit ThiophosphorylierungsreagenzienEuropean Journal of Inorganic Chemistry, 1978