The effect of indomethacin on autoregulation of renal blood flow in the anasthetized dog.

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Abstract
Renal blood flow autoregulation was studied in anesthetized greyhounds using an electromagnetic flowmeter, before and after the administration of the prostaglandin-synthesis inhibitor, indomethacin, or phosphate buffer. Indomethacin caused a reduction in renal blood flow at all levels of perfusion pressure, but did not affect the ability of the kidney to autoregulate. The abrupt reinstatement of renal perfusion pressure from previously reduced levels caused a triphasic transient response in flow. Peak hyperemia at the beginning of the transient was not affected by indomethacin. After indomethacin, the 2nd phase of this flow transient showed an oscillatory pattern during which flow fell initially to levels significantly lower than control. Although indomethacin did not abolish steady-state autoregulation, renal prostaglandins may damp rapid oscillations in renal blood flow and contribute to the efficiency of autoregulation.