Delayed Development of Pneumocystis Pneumonia Following Administration of Short-Term High-Dose Trimethoprim-Sulfamethoxazole
- 1 May 1978
- journal article
- research article
- Published by American Medical Association (AMA) in Archives of Pediatrics & Adolescent Medicine
- Vol. 132 (5) , 525-526
- https://doi.org/10.1001/archpedi.1978.02120300085018
Abstract
The incidence of opportunistic pulmonary infections in children with cancer who receive intensive immunosuppressive chemotherapy has increased.Pneumocystis cariniipneumonia (PCP) is a frequent cause of death in patients with acute lymphoblastic leukemia (ALL) who remain in complete remission.1.2At our institution, from Jan 1, 1975 to Dec 31, 1975, the incidence of PCP in children with ALL was 12% (11 of 89) while in patients with solid tumors the attack rate was 2% (one in 45). All patients with ALL in whom PCP developed were in remission and with only one exception, PCP occurred between days 40 and 90 from the onset of chemotherapy. Since PCP has been treated effectively in adults as well as children with a two-week course of high-dose Trimethoprim-Sulfamethoxazole (TMP-SMZ),3.4we evaluated the prophylactic value of this regimen in a random fashion in children with ALL who were in the first 100 daysKeywords
This publication has 1 reference indexed in Scilit:
- Trimethoprim-Sulfamethoxazole Treatment ofPneumocystis cariniiPneumonia in AdultsNew England Journal of Medicine, 1976