ALLERGIC REACTIONS TO LIVER EXTRACT

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Abstract
Reactions, especially milder ones, are not rare. Numerous severe reactions have been reported, but no fatalities. The make of extract and the dose have little relation to the occurrence of reactions. They usually occur after many well-tolerated injns., especially after a long injn.-free interval. The clinical manifestations are extremely varied, including practically every allergic sign and symptom. Direct and indirect intracut. tests with various brands of diluted extract are usually positive; similar tests with hog and beef muscle are practically always negative. Although a small number of the reported reactions are probably due to performed histamine, the large majority are on a true allergic basis. The sensitivity is to some substance possibly the anti-anemic factor[long dash]in liver extract, irrespective of its biological source (hog, beef, etc.). Desensitization with gradually increasing doses of diluted liver extract is recommended for patients who react frequently.

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