HIV-associated immune dysfunction and viral infection: role in the pathogenesis of AIDS-related lymphoma
- 18 August 2010
- journal article
- review article
- Published by Springer Nature in Immunologic Research
- Vol. 48 (1-3) , 72-83
- https://doi.org/10.1007/s12026-010-8168-8
Abstract
HIV infection is associated with a much higher risk for the development of non-Hodgkin lymphoma (AIDS-NHL). The principal causes of lymphomagenesis in HIV-infected individuals are thought to be the loss of immune function seen in HIV infection, which results in the loss of immunoregulation of Epstein-Barr virus-infected B cells, as well as HIV infection-associated immune dysregulation, including chronic B-cell activation. In this review, we discuss recent reports that further support the importance of these factors, and we highlight emerging evidence of different mechanisms that potentially drive lymphomagenesis in HIV-infected individuals.Keywords
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