Requirement for the Leukocyte-Specific Adapter Protein SLP-76 for Normal T Cell Development
- 17 July 1998
- journal article
- other
- Published by American Association for the Advancement of Science (AAAS) in Science
- Vol. 281 (5375) , 416-419
- https://doi.org/10.1126/science.281.5375.416
Abstract
The leukocyte-specific adapter molecule SLP-76 (Src homology 2 domain–containing leukocyte protein of 76 kilodaltons) is rapidly phosphorylated on tyrosine residues after receptor ligation in several hematopoietically derived cell types. Mice made deficient for SLP-76 expression contained no peripheral T cells as a result of an early block in thymopoiesis. Macrophage and natural killer cell compartments were intact in SLP-76–deficient mice, despite SLP-76 expression in these lineages in wild-type mice. Thus, the SLP-76 adapter protein is required for normal thymocyte development and plays a crucial role in translating signals mediated by pre–T cell receptors into distal biochemical events.Keywords
This publication has 22 references indexed in Scilit:
- αβ T Cell Development Is Abolished in Mice Lacking Both Lck and Fyn Protein Tyrosine KinasesImmunity, 1996
- Differential Regulation of Activation-induced Tyrosine Phosphorylation and Recruitment of SLP-76 to Vav by Distinct Isoforms of the CD45 Protein-tyrosine PhosphataseJournal of Biological Chemistry, 1996
- Vav and SLP-76 Interact and Functionally Cooperate in IL-2 Gene ActivationImmunity, 1996
- Implication of the GRB2-associated phosphoprotein SLP-76 in T cell receptor-mediated interleukin 2 production.The Journal of Experimental Medicine, 1996
- The pre-T cell receptor (TCR) complex is functionally coupled to the TCR-zeta subunit.The Journal of Experimental Medicine, 1995
- Essential role for ZAP-70 in both positive and negative selection of thymocytesNature, 1995
- Crucial role of the pre-T-cell receptor α gene in development of ap but not γδ T cellsNature, 1995
- Protein tyrosine kinase p56lck controls allelic exclusion of T-cell receptor β-chain genesNature, 1993
- Genetic evidence for the involvement of the lck tyrosine kinase in signal transduction through the T cell antigen receptorCell, 1992
- RAG-1-deficient mice have no mature B and T lymphocytesCell, 1992