Caries in Rats Fed Highly or Slightly Hydrolysed Lycasin®

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Abstract
Four groups of Wistar rats, 10-12 animals/group, were fed a diet containing: sucrose, 56%; highly hydrolyzed starch hydrolysate (Lycasin), 32%, and unmodified starch, 24%; slightly hydrolyzed Lycasin, 32%, and unmodified starch, 24%; and unmodified starch, 56%. All animals were infected with a mixture of 4 strains of Streptococcus mutans and were kept on the diet by use of an automatic feeding machine for 60 days. The caries activity was higher in the sucrose group in fissures and on smooth surfaces than in all the 3 other groups (P < 0.001). With a few exceptions only enamel lesions and slight dentine lesions on the sulcal surfaces were found in the animals fed Lycasin or starch. There was a slight tendency (P < 0.05) to higher caries scores in the group fed the highly hydrolysed Lycasin, containing 38% free sorbitol, than in the group fed the starch hydrolysate with only 12% free sorbitol (slightly hydrolyzed Lycasin). These differences in the cariogenicity between highly and slightly hydrolyzed Lycasin are discussed concerning oral conditions in man.

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