Probable genetic linkage between genes coding for platelet‐specific antigens of the PIA and bak systems

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Abstract
Studies of the inheritance of the platelet-specific alloantigens PIA1/PlA2 and Baka/Bakb in informative families provided evidence that the genes determining PlA and Bak antigens are in close genetic linkage (P = .004). In 154 normal, unrelated Caucasian subjects it was found that the antigen PIA1 is associated with Baka and the antigen PIA2 with Bakb more often than would be expected by chance (P < .05). Bak and PIA antigens are carried on platelet membrane glycoproteins IIb and IIIa, respectively, which are decreased or absent in the inherited platelet disorder Glazmann's thrombasthenia. Thus, the findings suggest that the defect in this disease involves two closely linked genes.