The safety of dexamethasone and hydroxyethyl starch in the multiply leukapheresed donor

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Abstract
A total of 23 leukaphereses were performed on 5 normal, healthy donors for the purpose of providing granulocyte transfusions to septic leukemia patients with granulocytopenia. Dexamethasone 7.25-7.50 mg was given orally 10-12 h prior to each donation, and an average of 304 ml of hydroxyethyl starch (HES) was given i.v. during each procedure. During the period of observation for each donor, there was no significant change of total leukocyte and platelet counts, total bilirubin, alkaline phosphatase, LDH[lactic dehydrogenase], SGOT[serum glutamic oxalacetic transaminase], creatinine, BUN]blood urea N], and uric acid determinations. Changes in the concentrations of serum protein, albumin, cholesterol and glucose were thought to be due to hemodilution. Partial thromboplastin and prothrombin times remained within normal limits following collection procedures. Hb levels decreased transiently following the 1st 3 leukaphereses in all donors, but fell progressively to 11.8 g/dl in 1 donor undergoing 7 procedures in a 35-day period. Dexamethasone and HES in these doses can be given safely to multiply leukapheresed donors.

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