Antibacterial Properties of Protamine and Histone

Abstract
Sensitization of gram-negative microorganisms to the inhibitors Tergitol-7 and tyrothricin by protamine and histone brought out the fact that these sensitizers also possess antibacterial properties. Protamine was found effec- tive for Eberthella typhosa, Shigella paradysenteriae, Escherichia coli and Neisseria catarrhalis in varying degrees at pH 8.1. Histone was equally active at an acid pH.