Clinical experience with cefotaxime in hospitalized patients

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Abstract
Cefotaxime, the first of the third-generation cephalosporin antibiotics, successfully treated a wide range of infections in seriously ill hospital patients (including bacteraemia, pneumonia and severe soft tissue infections), especially when caused by Gram-positive organisms. Haemophilus spp. and coliforms including antibiotic-resistant bacteria, such as methicillin-resistant staphylococci and aminoglycoside-resistant coliforms. There was minimal toxicity, even when combined with an aminoglycoside, and no excessive accumulation of the drug in patients with markedly impaired renal function. Major sepsis caused by Klebsiella and Pseudomonas aeruginosa did not respond well, although this probably reflected the severe underlying pathology in many of these patients.

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