Oncogene expression in related cancer lines differing in metastatic capacity
- 1 May 1988
- journal article
- research article
- Published by Springer Nature in Clinical & Experimental Metastasis
- Vol. 6 (3) , 201-211
- https://doi.org/10.1007/bf01782480
Abstract
Various murine tumor cell lines with different metastatic capacities were testedin vitro for oncogene expression, especially of the p21-Ha-ras protein. Small differences were seen in the expression of several distinct oncogenes in the case of a high metastatic lymphoma variant (ESb) and its low metastatic parental line (Eb). In one instance we observed a 30-fold Ha-ras gene amplification in a metastasis-derived cell line from a spontaneous mouse mammary carcinoma. In spite of this amplification we did not find an increased p21 expression in these cells.This publication has 66 references indexed in Scilit:
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