Excretion of Ether-Soluble Acids by Rats on Necrogenic Diet with and Without Supplements of Antibiotics.

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Abstract
The ether-soluble acid excretion in the urine of rats fed a necrogenic diet was detd. Rats on a necrogenic diet died between 30 and 60 days. These rats had a high rate of ether-soluble acid excretion. Rats supplemented with vit. E lived and had a high rate of ether-soluble acid excretion. Rats supplemented with aureomycin or penicillin by mouth lived, and had a low ether-soluble acid excretion. The ether-soluble acids in the non-hydrolyzed urine consist of p-aminobenzoic acid, hippuric acid, methyl malonic acid, alpha, alpha-dimethyl succinic acid and 2 unidentified acids. Methyl malonic acid forms a large part of the acid excretion of the non-supplemented and vit. E treated animals.

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