Anti (Streptococcal) Desoxyribonuclease. Occurrence in the Sera of Patients Treated with Streptococcal Concentrates Containing Streptodornase

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Abstract
Summary: Methods are described for assay of streptodornase and its specific antibody, antistreptodornase. Untreated subjects had a range of antistreptodornase titer from zero to 100 units per ml of serum; a titer of 500 units or more was considered elevated. An elevated titer was demonstrated in sera of patients nine days to one month after therapeutic administration of streptodornase; it persisted for one to three months. Titers were not altered by heating sera at 56 C for 30 minutes. Specificity was confirmed by failure of antistreptodornase to inhibit pancreatic desoxyribonuclease.