DECREASED LIVER AND LUNG DRUG-METABOLIZING ACTIVITY IN MICE TREATED WITH CORYNEBACTERIUM-PARVUM

  • 1 January 1976
    • journal article
    • research article
    • Vol. 36  (12) , 4425-4428
Abstract
Injections of killed suspensions of C. parvum (i.p.) in young male mice were followed by time- and dose-dependent decreases in the drug metabolizing activity of liver microsomes and lung homogenates. In vitro assays with model substrates [aminopyrine, aniline, p-nitroanisole, and benzo(a)pyrene] were used to quantitate drug metabolizing activity. Such decreases in mixed function oxidase activity will act to significantly alter the pharmacokinetics of concurrently or subsequently administered drugs. The results provide a possible mechanism to explain several previously reported immunochemotherapeutic interactions in cancer treatment.

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