Evaluation of a Combined HIV‐1/2 and HTLV‐I/II Assay for Screening Blood Donors
- 1 May 1995
- journal article
- Published by Wiley in Vox Sanguinis
- Vol. 68 (4) , 220-224
- https://doi.org/10.1111/j.1423-0410.1995.tb02576.x
Abstract
A combined immunoassay for the simultaneous detection of antibodies to HIV-1/2 and HTLV-I/II (Bioelisa, Launch Diagnostics) has been evaluated to determine its suitability for routine use in blood screening. 84,222 donations were tested from 76,452 donors. One HIV- and 1 HTLV-1-positive donor were identified. The specificity was 99.7%, and the sensitivity for anti-HIV-1, anti-HIV-2, and anti-HTLV-1 on 173 positive sera was 100%; 2 of 25 anti-HTLV-II-positive sera were non-reactive. Although the specificity of the assay is not as high as that of HIV-1/2 kits currently in UK transfusion use, the information gained about donor HTLV antibody status makes the test an attractive alternative to them.Keywords
This publication has 4 references indexed in Scilit:
- Prevalence of antibodies to human T cell leukaemia/lymphoma virus in blood donors in north London.BMJ, 1993
- Evaluation of an Enzyme Immunoassay for the Combined Detection of Antibodies to HIV-1, HIV-2, HTLV-I and HTLV-IIAIDS, 1992
- Sensitivity of HTLV-I antibody assays for HTLV-IIThe Lancet, 1991
- Evaluation of enzyme immunoassays for antibody to human T-lymphotropic viruses type I/IIThe Lancet, 1991