Systematic errors in manual area measurement of skewed chromatographic peaks
- 1 January 1982
- journal article
- research article
- Published by Royal Society of Chemistry (RSC) in The Analyst
- Vol. 107 (1275) , 606-610
- https://doi.org/10.1039/an9820700606
Abstract
The systematic errors inherent in four methods of manual graphical chromatographic peak-area measurement are examined. Skewed peaks are simulated based on the exponentially modified gaussian equation. The errors in the peak-area measurements are calculated as a function of peak asymmetry. The Condal-Bosch trapezoidal method is seen to be largely unaffected by peak skew.Keywords
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