The cold plate as a test of nociceptive behaviors: description and application to the study of chronic neuropathic and inflammatory pain models

Abstract
A cold plate apparatus was designed to test the responses of unrestrained rats to low temperature stimulation of the plantar aspect of the paw. At plate temperatures of 10°C and 5°C, rats with either chronic constriction injury (CCI) of the sciatic nerve or complete Freund's adjuvant (CFA) i