EFFECT OF PYRIDINE ALDOXIMES ON RESPONSE OF FROG RECTUS MUSCLE TO ACETYLCHOLINE
Open Access
- 1 September 1958
- journal article
- research article
- Published by Wiley in British Journal of Pharmacology and Chemotherapy
- Vol. 13 (3) , 288-290
- https://doi.org/10.1111/j.1476-5381.1958.tb00904.x
Abstract
The effects of pyridine-2, 3- and 4-aldoxime methiodide (PAM) on the isotonic contracture of the isolated frog rectus abdominis muscle elicited by acetylcholine have been studied. The potentiation to acetylcholine resulting from incubation with PAM isomers is reversible and may be related to the weak anticholinesterase property of these compounds. Concentrations of the isomers higher than those needed for maximal potentiation produce a reversible block of the muscle to acetylcholine. pH studies suggest that cations are responsible for the potentiating and blocking properties of the PAM isomers.Keywords
This publication has 8 references indexed in Scilit:
- OXIMES AND ATROPINE IN SARIN POISONINGBritish Journal of Pharmacology and Chemotherapy, 1957
- Pyridine-2-Aldoxime Methiodide and Poisoning by AnticholinesterasesScience, 1957
- Theoretical Pre-exponential Factors for Hydrogen Atom Abstraction Reactions1Journal of the American Chemical Society, 1957
- A specific antidote against lethal alkyl phosphate intoxication. II. Antidotal propertiesArchives of Biochemistry and Biophysics, 1956
- A specific antidote against lethal alkylphosphate intoxicationArchives of Biochemistry and Biophysics, 1956
- THE REVERSAL BY OXIMES OF NEUROMUSCULAR BLOCK PRODUCED BY ANTICHOLINESTERASESBritish Journal of Pharmacology and Chemotherapy, 1955
- THE REACTIVATION BY OXIMES AND HYDROXAMIC ACIDS OF CHOLINESTERASE INHIBITED BY ORGANO‐PHOSPHORUS COMPOUNDSBritish Journal of Pharmacology and Chemotherapy, 1955
- A powerful reactivator of alkylphosphate-inhibited acetylcholinesteraseBiochimica et Biophysica Acta, 1955