High Affinity and Selectivity of Some Tetrahydroprotoberberine Alkaloids for Rat Striatal3H-raclopride Binding Sites
- 1 November 1993
- journal article
- research article
- Published by Taylor & Francis in Natural Product Letters
- Vol. 3 (3) , 233-238
- https://doi.org/10.1080/10575639308043869
Abstract
Four tetrahydroprotoberberine alkaloids isolated from Guatteria ouregou and Guatteria schomburgkiana were tested for their ability to displace 3H-SCH23390 and 3H-raclopride from their specific dopaminergic striatal binding sites and to inhibit 3H-dopamine uptake by striatal synaptosomes. All of them displaced 3H-raclopride binding with a high affinity and a great selectivity. These data suggest that the tetrahydroprotoberberine skeleton could be very interesting for developing selective ligands of D2 dopamine receptors.Keywords
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