Prostaglandin E-2-9-ketoreductase in ovarian tissues
- 1 November 1979
- journal article
- research article
- Published by Bioscientifica in Reproduction
- Vol. 57 (2) , 489-496
- https://doi.org/10.1530/jrf.0.0570489
Abstract
Summary. The existence of the enzyme prostaglandin E-2-9-ketoreductase which can convert prostaglandin E-2 to prostaglandin F-2α was indicated in experiments with pig and human ovarian tissues in vitro, using radioimmunoassay methods and a superfusion technique. Further studies involving radiotracer techniques demonstrated that the enzyme was localized in the high-speed (105 000 g) supernatant fraction of human, pig and rat luteal tissue and human stromal tissue. The enzyme was shown to be NADPH-dependent and its activity in luteal tissue increased in the order:pig < human < rat.This publication has 9 references indexed in Scilit:
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