Effect of Adrenocorticotropic Hormone and Cortisone Therapy on Human Plasma Aminopeptidase Activity.

Publisher Website
Google Scholar
Abstract
In a small control series the normal range of human plasma L-leucylglycylglycine-splitting (LGGase) activity has been established. In 2 patients who responded to ACTH and cortisone therapy, the pre-treatment LGGase activities were abnormally high and, concurrent with clinical remissions, plasma LGGase activities fell to normal levels only to rise again with onset of clinical relapses after cessation of therapy. In 4 patients who did not respond to hormonal therapy, no change in plasma LGGase activity occurred irrespective of whether pre-treatment levels were high or normal. Plasma LGGase activity was normal in a patient with Gushing''s syndrome and in a patient with Addison''s disease but was significantly elevated in a 2d patient with Addison''s disease complicated by arthritis. These studies lend credence to the hypothesis that changes in plasma LGGase activity reflect changes in clinical status and are not necessarily mediated through the adrenal cortex.

This publication has 3 references indexed in Scilit: