Endothelin-1 in periaqueductal gray area of mice induces analgesia via glutamatergic receptors

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Abstract
By NMDA receptor antagonists (2-APV and MK-801) injected in the same area (2-APV) or by intraperitoneal route (MK-801). CNQX, a non-NMDA receptor antagonist, did not inhibit the ET-1 effects. Prazosin, an α1-adrenergic blocking agent, also prevented the ET-1 antinociceptive effect. We suggest that the activation of NMDA glutamatergic receptors in the PAG area may be a necessary step for ET-1 induced antinociception. *Corresponding author: Prof. Francesco Rossi, Institute of Pharmacology and Toxicology, Faculty of Medicine and Surgery, II University of Naples, Via Broggia 3, 80138 Naples, Italy. Tel.: 081-566-5877 or 566-5878; FAX: 081-566-5877. (Accepted 9 August 1995.) © Lippincott-Raven Publishers....