MULTIPLE NATURE OF 3RD COMPONENT OF GUINEA-PIG COMPLEMENT .2. SEPARATION AND DESCRIPTION OF 2 ADDITIONAL FACTORS BETA AND D PREPARATION AND CHARACTERIZATION OF 4 INTERMEDIATE PRODUCTS
- 1 January 1965
- journal article
- research article
- Vol. 8 (6) , 604-+
Abstract
Two factors essential for the lysis of EAC''142 cells are described and designated as [beta] and d. These factors are distinct from the C''3-subunits a, b and c described earlier; they can be separated by chemical procedures. A simple assay method for both factors is given. Four highly reactive intermediates, EAC''142, a; EAC''142, a,b; EAC''142 a b,[beta] and EAC''142, a,b,[beta],c can be prepared and characterized by their lytic reactivity pattern against different systems of incomplete C''3. Evidence is presented that the subunits of the C''3-system interact with EAC''142 in a sequential order corresponding to the formula a-b-[beta]-c-d.This publication has 4 references indexed in Scilit:
- MULTIPLE NATURE OF 3RD COMPONENT OF GUINEA-PIG COMPLEMENT .I. SEPARATION AND CHARACTERIZATION OF 3 FACTORS A B AND C ESSENTIAL FOR HAEMOLYSIS1965
- COMPONENTS OF GUINEA PIG COMPLEMENTThe Journal of Experimental Medicine, 1963
- RELATION OF A ß1-GLYCOPROTEIN OF HUMAN SERUM TO THE COMPLEMENT SYSTEMThe Journal of Experimental Medicine, 1960
- KINETIC STUDIES ON IMMUNE HEMOLYSIS .7. DECAY OF EAC'1,4,2, FIXATION OF C'3 AND OTHER FACTORS INFLUENCING THE HEMOLYTIC ACTION OF COMPLEMENT1954