Multiple serologic reactions and their relationship to clinical activity in systemic lupus erythematosus
Open Access
- 1 February 1984
- journal article
- research article
- Published by Wiley in Arthritis & Rheumatism
- Vol. 27 (2) , 132-138
- https://doi.org/10.1002/art.1780270203
Abstract
Analysis of the binding of serum from 56 systemic lupus erythematosus patients to native DNA (nDNA), denatured DNA (dDNA), poly I, poly(dT), RNA, and cardiolipin revealed multiple antigen binding in many of the sera. Raised levels of antibodies (IgG and/or IgM) to denatured DNA were found in the highest percentage (68%) of patients. A small subset of patients with multiple raised IgM antibodies, renal disease, and vasculitic skin rash was identified. No correlation between multiple serologic activity and clinical disease was found.This publication has 27 references indexed in Scilit:
- Polyspecificity of Monoclonal Lupus Autoantibodies Produced by Human-Human HybridomasNew England Journal of Medicine, 1983
- Production of autoantibodies by human-human hybridomas.Journal of Clinical Investigation, 1982
- Anti-poly(G)·poly(C) antibodies in the serum of patients with systemic lupus erythematosusClinical Immunology and Immunopathology, 1982
- Reaction of systemic lupus erythematosus antinative DNA antibodies with native DNA fragments from 20 to 1,200 base pairs.Journal of Clinical Investigation, 1980
- DNA antibody class, subclass, and complement fixation in systemic lupus erythematosus with and without nephritisClinical Immunology and Immunopathology, 1978
- Immunoglobulin classes of DNA binding activity in serum and skin in systemic lupus erythematosus.Journal of Clinical Investigation, 1977
- Correlation between levels of DNA antibodies and clinical disease activity in SLE.Annals of the Rheumatic Diseases, 1977
- Prognostic significance of DNA-binding capacity patterns in patients with lupus nephritis.Annals of the Rheumatic Diseases, 1975
- Immunoglobulin classes and IgG subclasses of human antinuclear antibodies: A correlation of complement fixation and the nephritis of systemic lupus erythematosusClinical Immunology and Immunopathology, 1973
- The γG subclass of antinuclear and antinucleic acid antibodiesArthritis & Rheumatism, 1972