In vitro inactivation of the neurotoxic action of β-bungarotoxin by the marine natural product, manoalide
- 1 August 1984
- journal article
- Published by Springer Nature in Cellular and Molecular Life Sciences
- Vol. 40 (8) , 864-865
- https://doi.org/10.1007/bf01951998
Abstract
The irreversible neurotoxic action of β-bungarotoxin (β-BuTx) can be prevented by preincubation of the toxin with manoalide, a non-steroidal anti-inflammatory agent. Manoalide was also found to inactivate purified phospholipase A2 and thus prevent hydrolysis of phosphatidylcholine. PLA2 is a component found in several neurotoxic venoms and is also a rate limiting enzyme important in phospholipid metabolism and prostaglandin synthesis in man.Keywords
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