Hemochromatotic Pigmentation of the Central Nervous System
- 1 October 1956
- journal article
- other
- Published by American Medical Association (AMA) in A.M.A. Archives of Neurology & Psychiatry
- Vol. 76 (4) , 355-368
- https://doi.org/10.1001/archneurpsyc.1956.02330280013002
Abstract
In 1942 Lewey and Govons1reported a case of hemochromatotic pigmentation of the central nervous system. Their patient showed progressive deafness and difficulty in walking, but had not evidenced any of the clinical signs of classical hemochromatosis or other visceral disturbance. For this reason, the autopsy was restricted to the head. The neurologic symptoms had persisted over a six-year period. In 1948 a similar case was recognized,2in which almost identical clinical disabilities had progressed over an interval of 16 years. The deposition of hemosiderin and hemofuscin was identical in distribution to the first-described case, namely, in peripheral zones of cortex and brain stem and periventricular regions, with especially severe involvement of the cerebellum, where crests of many folia had undergone extensive necrosis. Perusal of an article by Noetzel,3in which a similar distribution of iron pigment was attributed to old subarachnoid hemorrhage, was of interest, sinceKeywords
This publication has 0 references indexed in Scilit: