Picrotoxin was effective and caused no ill effects. It was used intraven., each cc. containing 3 mgs. One cc. was injected per min. until the corneal reflexes reappeared and the patient was roused by pain stimuli. Thereafter it was given in sufficient dosage to keep the patient a little restless. This required approx. 3-6 mgs. per hr., depending on the symptom severity. The average severe case required 100-150 mgs. mostly during the 1st 24 hrs. Giant bullae occurred frequently, always over pressure areas, apparently due to continued lack of blood supply from pressure. The occurrence of peripheral neuritis in 2 instances emphasized the importance of special nutritional therapy. Sulfapyridine was found very effective in combating associated pneumonia.