Heart transplantation in baboons using α1,3-galactosyltransferase gene-knockout pigs as donors: initial experience
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- 26 December 2004
- journal article
- research article
- Published by Springer Nature in Nature Medicine
- Vol. 11 (1) , 29-31
- https://doi.org/10.1038/nm1171
Abstract
Hearts from α1,3-galactosyltransferase knockout pigs (GalT-KO, n = 8) were transplanted heterotopically into baboons using an anti-CD154 monoclonal antibody–based regimen. The elimination of the galactose-α1,3-galactose epitope prevented hyperacute rejection and extended survival of pig hearts in baboons for 2–6 months (median, 78 d); the predominant lesion associated with graft failure was a thrombotic microangiopathy, with resulting ischemic injury. There were no infectious complications directly related to the immunosuppressive regimen. The transplantation of hearts from GalT-KO pigs increased graft survival over previous studies.Keywords
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