Warfarin and the Biochemistry of the Vitamin K Dependent Proteins
- 1 January 1987
- book chapter
- Published by Springer Nature
- Vol. 214, 17-46
- https://doi.org/10.1007/978-1-4757-5985-3_3
Abstract
The vitamin K-dependent proteins are a diverse group of molecules, all sharing the unique amino acid gamma carboxy glutamic acid (Gla). Gla is produced by the vitamin K-dependent post translational gamma carboxylation of selected glutamic acid residues, a step blocked by warfarin (Fig. 1). Gla-containing proteins have been most thoroughly studied in the blood coagulation system and bone but are found in other tissues such as the kidney. This review will focus on the blood coagulation system but will also touch on other Gla-containing proteins which shed light on common structural and functional features.Keywords
This publication has 47 references indexed in Scilit:
- Characterization of monoclonal antibodies against human protein C specific for the calcium ion‐induced conformation or for the activation peptide regionFEBS Letters, 1985
- Evolution of the proteases of blood coagulation and fibrinolysis by assembly from modulesCell, 1985
- Amino acid sequence of bovine protein Z: a vitamin K‐dependent serine protease homologFEBS Letters, 1985
- Kringles: modules specialized for protein bindingFEBS Letters, 1984
- Common evolutionary origin of the fibrin‐binding structures of fibronectin and tissue‐type plasminogen activatorFEBS Letters, 1983
- Partially carboxylated prothrombins II. Effect of γ-carboxyglutamyl residues on the properties of prothrombin fragment 1Biochimica et Biophysica Acta (BBA) - Protein Structure and Molecular Enzymology, 1982
- Partially carboxylated prothrombins I. Comparison of activation properties and purification of 1- and 0-carboxyglutamyl variantsBiochimica et Biophysica Acta (BBA) - Protein Structure and Molecular Enzymology, 1982
- Molecular weight of undegraded plasma factor VBiochemistry, 1981
- Comparison of prothrombin complex concentrate and vitamin K1 in oral anticoagulant reversal.BMJ, 1976
- Studies on Coumarin Anticoagulant DrugsCirculation, 1968