Unity in Function in the Absence of Consensus in Sequence: Role of Leader Peptides in Export
- 3 March 1989
- journal article
- Published by American Association for the Advancement of Science (AAAS) in Science
- Vol. 243 (4895) , 1156-1159
- https://doi.org/10.1126/science.2646712
Abstract
Passage of proteins across membranes during export from their site of synthesis to their final destination is mediated by leader peptides that paradoxically exhibit a unity of function in spite of a diversity of sequence. These leader peptides act in at least two stages of the export process: at entry into the pathway and subsequently during translocation across the membrane. How selectivity is imposed on the system in the absence of a consensus among the sequences of leader peptides is the main issue discussed here.Keywords
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